Saturday, May 26, 2012

Male fertility genes discovered

Friday, May 25, 2012

A new study has revealed previously undiscovered genetic variants that influence fertility in men. The findings, published by Cell Press on May 24th in the American Journal of Human Genetics, shed much-needed light on human reproduction and might provide answers for countless men suffering from infertility.

Despite its high incidence, infertility remains a sensitive topic. Some of the stigma surrounding infertility arises from a lack of known scientific causes. In fact, nearly a quarter of reported infertility cases remain unexplained. Research regarding the genetics of fertility has come primarily from studies involving infertile subjects. "Such studies have not been able to identify genes or pathways contributing to variation in natural human fertility," remarks Carole Ober, the lead author of the study. This is because numerous non-genetic factors, such as alcohol and tobacco use, certain medications, and disease history, can contribute to infertility.

Ober and her graduate student, G?l?m Kosova, at the University of Chicago have taken a different approach. By studying a founder population, the Hutterites, Ober's research maximizes genetic influences and minimizes non-genetic ones. The Hutterites are a branch of Anabaptists who conscribe to a common set of religious and social beliefs. "Hutterites [forbid] contraception and uniformly desire large families, providing an outstanding population in which to study the genetics of normal human fertility," explains Ober. Rather than studying infertile subjects, the team included Hutterite men who had one or more child, and it took both family size and birth rate into consideration.

The study uncovered more than 40 genetic regions that influence fertility in Hutterite men. Nine of these regions were additionally found to impact sperm quality in non-Hutterites. These regions harbor genes involved in several essential biological processes, including protein regulation, nucleotide binding, and immunity, and shed light on the complexity of human fertility. Ultimately, says Ober, further studies might find that mutations in these genes underlie some of the currently unexplained cases of male infertility.

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Cell Press: http://www.cellpress.com

Thanks to Cell Press for this article.

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History: George Washington Tab form City Tavern, Philadelphia, September 1787

While reviewing the?information?for the?Constitutional Convention as a Four-Act Drama post, this caught my eye @ TeachingAmericanHistory.org:

Working through this huge and amazing array of material, I came across the menu and bill for the Farewell Dinner for George Washington on Friday, September 14, 1787 hosted by the First Troop Philadelphia City Cavalry. A related bill for 7 pounds 10 shillings to pay the musicians suggests that the dinner took place on Friday the 14th of September and Thomas Proctor submitted the bill on Saturday the 15th of September.

If this menu and bill for the 14th of September has been preserved, perhaps the menu and bill for the Framers? Farewell dinner on Monday the 17th of September can be found? Wouldn?t it be lovely if that could be recovered and added to the story of the American Founding? That was what was on my mind as I continued to search through the material.

Neither Kimball nor I were able to locate the menu or bill for the Framers? Farewell at the City Tavern. And, to the best of my knowledge, no such an item is available. So the menu and bill from the Washington Farewell is the closest we have both in terms of time and possible authenticity.

Be sure to read the rest of the write up @ TeachingAmericanHistory, it is very interesting.

And here?s the tab.

Part One:
Menu for Gentlemen and Musicians

?

First Troop Philadelphia City
Cavalry Archives, 1774
City Tavern
George Washington
Entertainment of
15 Sept., 1787

Light Troop of Horse, September the 14th 1787

?

?

To 55 Gentlemans Dinners & Fruit
Rellishes, Olives etc????????????? ?20 ?12 ??6
54 Bottles of Madera????????????.. ?20 ??5
60 of Claret ditto?????????????? ?21
8 ditto of Old Stock????????????? ??3 ??6 ??8
22 Bottles of Porter ditto??????????? ??2 ?15
8 of Cyder ditto??????????????? ?16
12 ditto Beer???????????????? ?12
7 Large Bowels of Punch???????????. ??4 ??4
Segars Spermacity candles etc????????. ??2 ??5
To Decantors Wine Glass [e]s & Tumblers Broken etc????? ??1 ??2 ??6
To 16 Servants and Musicians Dinners???????????.. ??2
16 Bottles of Claret?????????????. ??5 ?12
5 ditto Madera???????????????.. ??1 ?17 ??6
7 Bouls of Punch??????????????.. ??2? ?16? ????
?89 ??4 ??2

Musich- [?]
SSB??3/15/55

Part Two:
Bill for Musicians

?

First Troop Philadelphia City
Cavalry Archives, 1774
City Tavern
George Washington
Entertainment of
15 Sept., 1787

Col. Thomas Proctor to George Christhilf Dr.
To Musical Permormance [sic] at the City Tavern the 15th instant

?

? / d
George Christlift??????????????.. 1
Mr. Schultz????????????????.. 1
Mr. Treniner???????????????? 1
John Keyser????????????????. 15
Wm. Hartung???????????????.. 15
Philip Rotti????????????????.. 15
David Kartzrock??????????????.. 15
John Bruner???????????????? 15
Conrad Spangenberg???????????? 15
?7 10

Dear Sir
Be prepared to Order payment to the above sum of six pounds ten-to the Musicians

?

Sept 15th, 1787
Mr John Dunlap
Your Obd Servant
[Thos Proctor]

[on other side of the bill]

?

Rec?d Sept 15th 1787 of Samuel Miles Seven pounds Ten shillings in full of the within
accpt
??7.10

Who says history is boring?

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